2-Amino-3-Hydroxypyridine CAS 16867-03-1
2-Amino-3-Hydroxypyridine CAS 16867-03-12-Amino-3-Hydroxypyridine CAS 16867-03-1

2-Amino-3-Hydroxypyridine CAS 16867-03-1

2-Amino-3-Hydroxypyridine CAS 16867-03-1, 2-Amino-3-Hydroxypyridine, CAS 16867-03-1

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Alternative names: 3-hydroxy-2-aminopyridine, 2-amino-3-pyridinol (commonly found in supplier documentation)

16867-03-1

C5H6N2O

110.11

240-886-8

2-Amino-3-Hydroxypyridine CAS 16867-03-1 Information

CAS 16867-03-1
Molecular formula C5H6N2O
Molecular weight 110.11
EIENCS 240-886-8
Form Crystalline Powder
Melting point 168-172°C
boling point 206.4°C
Density 1.2111
Solubility DMSO (Slightly), Methanol (Slightly)
PKA 5.15±0.10(Predicted)
Color Grayish-beige to brownish
Storage temp Keep in dark place,Sealed in dry,Room Temperature

2-Amino-3-Hydroxypyridine CAS 16867-03-1

What is 2-Amino-3-Hydroxypyridine CAS 16867-03-1?

Molecules and Structures

Molecular formula: C₅H₆N₂O

Molecular weight: 110.11-110.12

Alternative names: 3-hydroxy-2-aminopyridine, 2-amino-3-pyridinol (commonly found in supplier documentation)

Appearance

High purity: Off-white crystals or white powder (≥99%)

Industrial grade: Light yellow to brown solid (affected by oxidation)

Melting and boiling points

Melting point: 170-176°C (common range in literature)

Boiling point: 385.2°C (760 mmHg)

Physicochemical parameters

Solubility: Readily soluble in water (263 g/L), methanol; Slightly soluble in chloroform

Stability: It has strong hygroscopicity and should be stored in a sealed container away from light. Long-term exposure is prone to oxidation and discoloration

Hazard Identification

UN 2811 (Class 6.1 toxic substance), R25 (toxic if swallowed), R36/37/38 (irritating to eyes/respiratory tract/skin)


2-Amino-3-Hydroxypyridine CAS 16867-03-1 Use

Pharmaceutical synthesis

Core uses: A key intermediate for anti-AIDS drugs (such as protease inhibitors) and prostaglandin synthase inhibitors

Derivative development: It is used for the synthesis of antipyretic and analgesic drugs (such as acetaminophen analogues), antibacterial drugs and anti-tumor compounds

Industry and daily chemicals

Dye industry

Hair dye components (diazo dye precursors)

Dyeing intermediates for wool and polyamide fibers

Pesticides and Veterinary Drugs: Synthetic insecticide methylpyridinium

Scientific research application

Construct nitrogen-containing heterocyclic compounds, such as 2-(BOc-amino) -3-hydroxypyridine, for polypeptide modification


2-Amino-3-Hydroxypyridine CAS 16867-03-1 safety

Health risk

Acute toxicity: Oral LD₅₀=301 mg/kg in rats, inhalation of dust causes respiratory tract damage

Chronic exposure: Long-term exposure may cause abnormal liver and kidney functions (IARC has not confirmed carcinogenicity).

Operation protection

Essential equipment: Gas mask, chemical protective suit, acid-resistant gloves and goggles (Safety terms: S26/S36/S37)

Leakage treatment: After adsorption by sand and soil, transfer to hazardous waste disposal. Do not use water flushing (to avoid diffusion).

Storage requirements

Seal and keep away from light. Cool and dry (≤25℃), away from oxidants and strong acids


Deshangchemical Info

  • ● Comgpany name : Shandong Deshang Chemicals Co., Ltd.
  • ● Main products : Treatments, sedimentation agents, flame retardants, catalysts, matte pigments, talcum powder, PVC additives, antifreeze agents, cellulose, cleaning agents, coconut oil, hydroxyethyl, cosmetics, matte agents, betaine, disinfectants, photosensitizers, humidifying agents, blue pigments, curing agents, potassium formate, sodium formate, cyclohexanol, preservatives, grinding aids.
  • ● Date of establishment : 2022-03-11
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  • ● Registered capital: 10000000 RMB
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