2-Amino-3-Hydroxypyridine CAS 16867-03-1

2-Amino-3-Hydroxypyridine CAS 16867-03-1 Information

CAS	16867-03-1
Molecular formula	C5H6N2O
Molecular weight	110.11
EIENCS	240-886-8
Form	Crystalline Powder
Melting point	168-172°C
boling point	206.4°C
Density	1.2111
Solubility	DMSO (Slightly), Methanol (Slightly)
PKA	5.15±0.10(Predicted)
Color	Grayish-beige to brownish
Storage temp	Keep in dark place,Sealed in dry,Room Temperature

What is 2-Amino-3-Hydroxypyridine CAS 16867-03-1?

Molecules and Structures

Molecular formula: C₅H₆N₂O

Molecular weight: 110.11-110.12

Alternative names: 3-hydroxy-2-aminopyridine, 2-amino-3-pyridinol (commonly found in supplier documentation)

Appearance

High purity: Off-white crystals or white powder (≥99%)

Industrial grade: Light yellow to brown solid (affected by oxidation)

Melting and boiling points

Melting point: 170-176°C (common range in literature)

Boiling point: 385.2°C (760 mmHg)

Physicochemical parameters

Solubility: Readily soluble in water (263 g/L), methanol; Slightly soluble in chloroform

Stability: It has strong hygroscopicity and should be stored in a sealed container away from light. Long-term exposure is prone to oxidation and discoloration

Hazard Identification

UN 2811 (Class 6.1 toxic substance), R25 (toxic if swallowed), R36/37/38 (irritating to eyes/respiratory tract/skin)

2-Amino-3-Hydroxypyridine CAS 16867-03-1 Use

Pharmaceutical synthesis

Core uses: A key intermediate for anti-AIDS drugs (such as protease inhibitors) and prostaglandin synthase inhibitors

Derivative development: It is used for the synthesis of antipyretic and analgesic drugs (such as acetaminophen analogues), antibacterial drugs and anti-tumor compounds

Industry and daily chemicals

Dye industry

Hair dye components (diazo dye precursors)

Dyeing intermediates for wool and polyamide fibers

Pesticides and Veterinary Drugs: Synthetic insecticide methylpyridinium

Scientific research application

Construct nitrogen-containing heterocyclic compounds, such as 2-(BOc-amino) -3-hydroxypyridine, for polypeptide modification

2-Amino-3-Hydroxypyridine CAS 16867-03-1 safety

Health risk

Acute toxicity: Oral LD₅₀=301 mg/kg in rats, inhalation of dust causes respiratory tract damage

Chronic exposure: Long-term exposure may cause abnormal liver and kidney functions (IARC has not confirmed carcinogenicity).

Operation protection

Essential equipment: Gas mask, chemical protective suit, acid-resistant gloves and goggles (Safety terms: S26/S36/S37)

Leakage treatment: After adsorption by sand and soil, transfer to hazardous waste disposal. Do not use water flushing (to avoid diffusion).

Storage requirements

Seal and keep away from light. Cool and dry (≤25℃), away from oxidants and strong acids

Deshangchemical Info

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