Azithromycin Powder CAS 83905-01-5
Azithromycin Powder CAS 83905-01-5Azithromycin Powder CAS 83905-01-5

Azithromycin Powder CAS 83905-01-5

Azithromycin Powder CAS 83905-01-5, Azithromycin Powder, CAS 83905-01-5

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Molecular formula: C₃₈H₇₂N₂O₁₂,Molecular weight: 748.98,Appearance: White or off-white crystalline powder, odorless, bitter in taste, slightly hygroscopic.

83905-01-5

C38H72N2O12

748.98

617-500-5

Azithromycin Powder CAS 83905-01-5 Information

CAS 83905-01-5
Molecular formula C38H72N2O12
Molecular weight 748.98
EIENCS 617-500-5
Form neat
Melting point 113-115°C
boling point 822.1±65.0°C
Density 1.18±0.1 g/cm3
Solubility It is almost insoluble in water but readily soluble in methanol, acetone, anhydrous ethanol and dilute hydrochloric acid
PKA pKa 8.74 (H2O t=25 I=0.167) (Uncertain);9.45(H2O t=25 I=0.167) (Uncertain)
Color White to Off-White
Storage temp

Azithromycin Powder CAS 83905-01-5

What is Azithromycin Powder CAS 83905-01-5?

Molecules and physicochemical properties

Molecular formula: C₃₈H₇₂N₂O₁₂

Molecular weight: 748.98

Appearance: White or off-white crystalline powder, odorless, bitter in taste, slightly hygroscopic.

Solubility: Almost insoluble in water, readily soluble in methanol, acetone, anhydrous ethanol and dilute hydrochloric acid.

Melting and boiling points: Melting point 113-115°C, boiling point 822.1°C (760 mmHg).

Specific rotation: -45° to -49° (20mg/ml anhydrous ethanol solution).

Quality standard

Purity requirement: For pharmaceutical grade, calculated as anhydrous matter, it should reach 96.0% - 102.0%.

Heavy metal limit: Some suppliers (such as Qiaofeng Chemical) require it to be ≤1ppm.


Azithromycin Powder CAS 83905-01-5 Use

Mechanism of action

By binding to the 50S ribosome subunit of bacteria, it inhibits protein synthesis and blocks bacterial growth.

Antibacterial spectrum and indications

Gram-positive bacteria: Streptococcus pneumoniae, Staphylococcus aureus.

Gram-negative bacteria: Haemophilus influenzae, Moraxella catarrhalis.

Atypical pathogens: Mycoplasma pneumoniae, Chlamydia (the preferred drug for mycoplasma pneumonia in children).

Main uses: Respiratory tract infections (pneumonia, bronchitis), reproductive and urinary tract infections (chlamydia urethritis), skin and soft tissue infections.

Pharmacokinetic characteristics

The oral bioavailability is 37%, with a half-life of 35 to 48 hours, and the tissue concentration can reach 10 to 100 times that of blood.

50% is excreted through the biliary tract, and 4.5% is excreted through urine.


Azithromycin Powder CAS 83905-01-5 safety

Toxicity Warning

Hazard category code 42/43 (potentially allergenic). Protective equipment (S22, S36/37) must be worn during operation.

The FDA warns: It may pose a risk of heart disease. People with a history of arrhythmia should use it with caution.

Contraindications: This product is contraindicated in patients allergic to azithromycin and those with severe liver dysfunction.

Drug interactions

When used in combination with warfarin, it may prolong the coagulation time, and when used in combination with ergol derivatives, it increases the risk of poisoning


Deshangchemical Info

  • ● Comgpany name : Shandong Deshang Chemicals Co., Ltd.
  • ● Main products : Treatments, sedimentation agents, flame retardants, catalysts, matte pigments, talcum powder, PVC additives, antifreeze agents, cellulose, cleaning agents, coconut oil, hydroxyethyl, cosmetics, matte agents, betaine, disinfectants, photosensitizers, humidifying agents, blue pigments, curing agents, potassium formate, sodium formate, cyclohexanol, preservatives, grinding aids.
  • ● Date of establishment : 2022-03-11
  • ● Total Employees : 200+
  • ● Registered capital: 10000000 RMB
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