Cordycepin CAS 73-03-0, Cordycepin, CAS 73-03-0
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Cordycepin (CAS 73-03-0), as the core active component of Cordyceps militaris, has become a hot spot in the research and development of medicine and health products due to its multi-target anti-tumor, immune balance and organ protection effects. Its safety (low mutagenicity) and source controllability (artificially cultivated Cordyceps militaris) support industrial development.
73-03-0
C10H13N5O3
251.24
200-791-4
| CAS | 73-03-0 |
| Molecular formula | C10H13N5O3 |
| Molecular weight | 251.24 |
| EIENCS | 200-791-4 |
| Form | Powder |
| Melting point | 225-229 °C |
| boling point | 394.4°C (rough estimate) |
| Density | 1.2938 (rough estimate) |
| Solubility | Soluble in DMSO (up to 25 mg/ml). |
| PKA | 13+-.0.60(Predicted) |
| Color | White to Off-white |
| Storage temp | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
Pharmacological effects and biological activities
Core pharmacological mechanism
Anti-tumor effect:
Inhibit RNA/DNA synthesis in tumor cells and block nucleotide phosphorylation;
Induce apoptosis of cancer cells (such as leukemia, melanoma, lung cancer), and activate the Caspase pathway;
When combined with chemotherapy drugs (such as cisplatin), it can significantly enhance the effect (for example, the tumor inhibition rate of S180 sarcoma is increased to 88.55%).
Immune regulation
Promote the secretion of IL-10, inhibit the production of IL-2, and balance the immune response;
Enhance the phagocytic ability of macrophages and the transformation of T lymphocytes.
Anti-inflammation and anti-infection
Inhibit the replication of Bacillus subtilis, Mycobacterium tuberculosis and HIV-1 virus;
Reduce airway inflammation in asthma models and improve the pathological changes of COPD.
Organ protection
Lung: Alleviate fibrosis and repair airway remodeling;
Kidney: Inhibits high glucose-induced renal interstitial fibrosis and regulates the TGF-β/Smad pathway;
Nerves: Delay the apoptosis of hypoxic neurons and improve neurological function after cerebral hemorrhage.
Medicine
Phase III clinical trial in the United States: Treatment of acute lymphoblastic leukemia;
Phase I clinical trial in China: New leukemia drug (Cordycepin derivative).
Health supplements
Capsules/Tablets (20-60 mg daily) : Enhance immunity, fight fatigue, and regulate the three highs.
Cordyceps wine: Ethanol enhances the absorption rate of cordycepin.
Cosmetics
Antioxidant essence: Eliminates free radicals and reduces wrinkles (concentration 0.2-5%).
Food industry
Functional additives: Beverages, dairy products (subject to the limits stipulated in GB 2760).
Acute toxicity: Oral administration of LD₅₀ in rats = 2220-3890 mg/kg (low to moderate toxicity);
Genotoxicity
Non-mutagenic (negative in the Ames test)
DNA damage threshold of human fibroblasts: 500 μmol/L
GHS identification:
H301 (toxic when swallowed), H315 (skin irritation), H319 (severe eye damage);
Protective suggestions: Wear gloves and goggles during operation to avoid inhaling dust.
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