Cyanoacetic acid CAS 372-09-8
Cyanoacetic acid CAS 372-09-8Cyanoacetic acid CAS 372-09-8

Cyanoacetic acid CAS 372-09-8

Cyanoacetic acid CAS 372-09-8, Cyanoacetic acid, CAS 372-09-8

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Molecular formula: C₃H₃NO₂ (NCCH₂COOH),Molecular weight: 85.06,Appearance: White crystals or powder, with strong hygroscopicity. It may turn slightly yellow after long-term storage.

372-09-8

C3H3NO2

85.06

206-743-9

Cyanoacetic acid CAS 372-09-8 Information

CAS 372-09-8
Molecular formula C3H3NO2
Molecular weight 85.06
EIENCS 206-743-9
Form Adhering Crystalline Solid
Melting point 65°C
boling point 108°C0.15 mm Hg
Density 1.3676
Solubility H2O: soluble50mg/mL, clear, colorless to very faintly yellow
PKA 2.45(at 25℃)
Color White to light beige
Storage temp Store below +30°C.

Cyanoacetic acid CAS 372-09-8

What is Cyanoacetic acid CAS 372-09-8?

Molecules and Structures

Molecular formula: C₃H₃NO₂ (NCCH₂COOH)

Molecular weight: 85.06

Appearance: White crystals or powder, with strong hygroscopicity. It may turn slightly yellow after long-term storage.

Melting and boiling points

Melting point: 65-68℃

Boiling point: 108℃ (under 2.0kPa pressure reduction).

Solubility

Readily soluble in water (263 g/L, 20℃), ethanol and ether;

Slightly soluble in benzene, chloroform and acetic acid.

Chemical properties

Acidity: pKa≈2.45, which is more acidic than common carboxylic acids (due to the electron-withdrawing effect of the cyanogenic group).

Stability

Decomposition at 160℃ → acetonitrile (highly toxic) + CO₂;

It releases hydrogen cyanide (HCN) when exposed to strong acids.

Reactivity

It participates in reactions such as esterification (to form cyanoacetate) and Knoevenagel condensation (to synthesize α,β -unsaturated nitriles).


Cyanoacetic acid CAS 372-09-8 Use

Pharmaceutical synthesis

Key intermediate

Vitamin B₆ caffeine barbiturate sedatives;

Medical adhesive (methyl α -cyanoacrylate).

Anti-cancer drugs: synthetic sulin acid, etc.

Pesticide industry

Fungicide: thiamine cyanide (for controlling oomycetes disease)

Herbicides: Precursors for synthetic sulfonylurea herbicides.

Chemical Engineering and Materials

Resin modification: Enhancing heat resistance (such as hindered amine light stabilizers);

Dye synthesis: C.I. basic Yellow 90/96 and other azo dyes;

Metal treatment: Surface degreaser.


Cyanoacetic acid CAS 372-09-8 safety

Toxicity data

Acute toxicity: Oral LD₅₀=400-800 mg/kg in guinea pigs; Oral LD₅₀=1500 mg/kg in rats;

Irritation: Skin corrosion, eye damage.

Hazardous characteristics

Corrosiveness: Burns upon contact with skin, releases HCN (highly toxic) upon contact with acid;

Explosion risk: Flammable (flash point 107℃), dust can explode.

Protection and Emergency Response

Operating equipment: Gas mask (full face mask), nitrile gloves, anti-corrosion suit;

Leakage treatment: Sand and soil adsorption → hazardous waste incineration (water flushing is prohibited)

Storage conditions: Sealed and protected from light, ≤30℃; Stay away from acids/oxidants.

Transport marking

UN 3261 (Class 8 corrosives, Class II packaging)


Deshangchemical Info

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