Diisobutylaluminium Hydride CAS 1191-15-7

Diisobutylaluminium Hydride CAS 1191-15-7 Information

CAS	1191-15-7
Molecular formula	C8H19Al
Molecular weight	142.22
EIENCS	214-729-9
Form	Solution
Melting point	-70 °C
boling point	65 °C
Density	1.23 g/mL at 25 °C
Solubility	Miscible with organic solvents.
PKA	/
Color	Clear
Storage temp	2-8°C

What is Diisobutylaluminium Hydride CAS 1191-15-7?

Restoration characteristics:

Selective reduction: By regulating the temperature (-78°C to 70°C), highly selective reduction of functional groups can be achieved.

Ester/lactone → Aldehyde/hemiacetal (low temperature, partial reduction);

Nitrile → aldehyde (hydrolyzed by imine intermediate)

Ketone/carboxylic acid → Alcohol (completely reduced).

Hydroalumination reaction: It undergoes cis-addition with alkynes to form an alkenyl aluminum intermediate, which is used in subsequent halogenation, carbonylation and other derivative reactions.

Stability and Danger:

Highly flammable (flash point 40°F/4°C), reacts violently with water to release hydrogen gas;

Strong corrosiveness: Can cause severe skin burns and eye damage (GHS label: ⚠️ Hazard, H314);

Air sensitive: It should be operated without water or oxygen and stored in an inert gas environment (such as argon).

Diisobutylaluminium Hydride CAS 1191-15-7 Use

Organic synthesis reducing agent

Partial reduction of esters/lactones: Converting esters to aldehydes at low temperatures (superior to the traditional reduction-oxidation route);

The reduction of nitriles to aldehydes: A key step in the synthesis of drug intermediates (such as the anti-cancer drug eribrine mesylate);

Epoxy isomerization: generating allyl alcohol compounds.

Industrial Catalysis and Materials

Polymer catalyst: Promotes the synthesis of polyolefins;

Synthesis of fine chemicals: such as citronellol and polyenal fragrances.

Drug research and development

It is used in the coupling reaction of antiviral drugs (such as Paxlovid intermediates) and anti-cancer drugs (eribrine).

Diisobutylaluminium Hydride CAS 1191-15-7 safety

Protective measures:

Operating requirements: Wear chemical protective gloves, goggles and a gas mask in the fume hood.

Leakage treatment: Adsorb with sand and soil. Do not rinse with water (to avoid hydrogen explosion).

Post-processing steps (refer to the standard process) :

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1. Dilute the ether and cool to 0°C;

2. Slowly add 0.04 times the volume of water;

3. Add 0.04 times the volume of 15% NaOH solution;

4. Heat to room temperature and stir for 15 minutes;

5. Filtration and desalination (anhydrous MgSO₄ as an auxiliary).

Storage conditions:

Store in a light-proof sealed container at -20°C to 8°C (argon gas protection is recommended).

Keep away from oxidants, acids and humid environments.

Deshangchemical Info

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