Diisopropyl Malonate CAS 13195-64-7, Diisopropyl Malonate, CAS 13195-64-7
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Chemical Name: Diisopropyl malonate (Alternative name: Di (1-methylethyl) malonate)
13195-64-7
C9H16O4
188.22
236-156-3
| CAS | 13195-64-7 |
| Molecular formula | C9H16O4 |
| Molecular weight | 188.22 |
| EIENCS | 236-156-3 |
| Form | / |
| Melting point | -51°C(lit.) |
| boling point | 93-95 °C/12 mmHg (lit.) |
| Density | 0.991 g/mL at 25 °C (lit.) |
| Solubility | / |
| PKA | / |
| Color | / |
| Storage temp |
Chemical Name: Diisopropyl malonate (Alternative name: Di (1-methylethyl) malonate)
Molecular formula: C₉H₁₆O₄
Molecular weight: 188.22 g/mol
CAS Number: 13195-64-7
EINECS number: 236-156-3
Appearance: Colorless and transparent liquid (industrial products are slightly yellow), with a faint ester odor
Solubility: Insoluble in water, readily soluble in esters (such as ethyl acetate), benzene, ether and other organic solvents
Mainstream process (sulfuric acid catalytic esterification method) :
Raw materials: Sodium malonate, isopropanol, benzene (solvent).
Step:
Sodium malonate and benzene are mixed in the reactor and heated to 60-70℃.
Add concentrated sulfuric acid dropwise and keep the reaction warm for 3 to 4 hours.
The crude product was separated after water washing and alkali washing, and the fraction at 99-100℃ was collected by vacuum distillation (177.8 Pa).
Yield: Approximately 85%, purity ≥99%.
Technical optimization
Green process: Develop biocatalytic technology to reduce the usage of sulfuric acid (lower wastewater discharge).
Continuous production: Hubei enterprises have adopted fixed-bed reactors, increasing production capacity by 20%.
Pesticide intermediates (main uses)
Synthetic Rice Blast: As a key intermediate of fungicides, it is used to control rice blast and rice planthopper (accounting for 30% of global pesticide demand).
Other pesticide enhancers: Enhance the penetration of insecticides and reduce the amount of pesticides used in agriculture.
Synthesis of medicine and spices
Drug intermediates: Used in the synthesis of antibiotics (such as cephalosporins), anti-cancer drugs and cardiovascular drugs (accounting for 40% of the medical demand).
Spice ingredients: Endow cosmetics and food with unique fragrances (such as citrus essence).
Industrial materials
Plastic plasticizer: Improves the flexibility of polymers and is used in PVC and rubber products.
Coating additives: Enhance the leveling and adhesion of coatings (architectural/automotive paints).
Emerging fields
Biodegradable plastics: Develop bio-based polyester resins to replace petroleum-based materials.
Electronic chemicals: For high-purity cleaning agents and etching solutions (in semiconductor manufacturing).
Health risk:
Irritation: Contact with skin/eyes can cause inflammation (R36/37/38), and inhalation of vapor can cause respiratory discomfort.
Toxicity: Oral LD₅₀ > 2000 mg/kg in rats (actually non-toxic). A gas mask and acid and alkali resistant gloves are required for operation.
Storage and transportation
Cool and well-ventilated (≤30℃), away from light and sealed, with a relative humidity of less than 75%.
Transportation mark: UN 1993 (Flammable Liquid).
Environmental protection compliance
Export requires REACH certification; The pharmaceutical grade needs to comply with the FDA/GB 10287 standard.
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