Dimethylaminoethyl Acrylate CAS 2439-35-2

Dimethylaminoethyl Acrylate CAS 2439-35-2 Information

CAS	2439-35-2
Molecular formula	C7H13NO2
Molecular weight	143.18
EIENCS	219-460-0
Form	clear liquid
Melting point	-60°C
boling point	64 °C12 mm Hg(lit.)
Density	0.943 g/mL at 25 °C(lit.)
Solubility	Soluble in water (1.000 g/L at 20°C).
PKA	8.21±0.28(Predicted)
Color	Colorless to Light yellow to Light orange
Storage temp	2-8°C

What is Dimethylaminoethyl Acrylate CAS 2439-35-2?

Dimethyloxyethyl acrylate (DMAEA) is a key monomer for water treatment, biomedicine and smart materials due to its bifunctional reactivity and pH-responsive properties. Its safety needs to be strictly controlled (such as the addition of anti-agglomerating agents and protective equipment), and the design of block copolymers is driving its innovative applications in precision medicine. Future research should focus on: 

Deepening of toxicity mechanism: Clarify the impact of chronic exposure on the reproductive system;

Improvement of biocompatibility: Develop low-toxicity copolymer structures (such as PEG modification);

Scaling up of green production: Optimize catalytic processes to reduce BDO dependence.

Functional group characteristics

Dual reaction sites:

Acrylate group: Participates in free radical polymerization (e.g., copolymerization with acrylamide, styrene).

Tertiary amine group (-N(CH₃)₂): Provides pH responsiveness. Under acidic conditions, it is protonated to form a cation, enhancing hydrophilicity and charge interaction.

Self-polymerization tendency: Sensitive to light and heat, requires the addition of a stabilizer (such as MEHQ, with a content of 1000-2000 ppm).

Polymerization behavior

Homopolymer/Copolymer: Can synthesize linear or block polymers, precisely controlling molecular weight and structure through RAFT polymerization.

Intelligent responsiveness:

pH response: Solubility changes after protonation (pKa ≈ 8.2), suitable for controlled-release carriers.

Temperature synergy: When copolymerized with NIPAM blocks, it exhibits dual-response self-assembly (such as micelle formation) under temperature/pH conditions.

Dimethylaminoethyl Acrylate CAS 2439-35-2 Use

1. Industrial Chemical Synthesis

Water treatment flocculants: Form cationic poly electrolytes through copolymerization with acrylamide, effectively adsorbing suspended particles.

Oilfield chemicals: As drilling fluid additives, they improve clay stability and rheological properties.

Anti-static coatings: The copolymer is used in electronic packaging materials to eliminate static charge accumulation. 

2. Biomedical Materials

Drug Delivery Systems:

Block copolymers (such as PNIPAM-b-PDEAEAM) release drugs in the tumor microenvironment (pH 6.5).

Cationic nucleic acid (DNA/RNA) complexes are used for gene vector design.

Antibacterial agents: Protonated polymers disrupt bacterial membranes (such as medical device coatings).

3. Functional Polymers

Smart-responsive materials: Respond to environmental changes (such as temperature/pH) in sensors and self-repairing coatings.

Papermaking additives: Enhance fiber bonding strength and improve paper strength.

Dimethylaminoethyl Acrylate CAS 2439-35-2 safety

Risk classification 

Health risks :

Acute toxicity (oral/dermal): LD₅₀ not specified, but classified as extremely toxic (T+).

Stinginess and sensitization: Skin contact causes burns (R34), eye irritation (R36), may cause sensitization (R43).

Environmental toxicity: Highly toxic to aquatic organisms (R50), leakage to water bodies must be prevented.

Operation and storage 

Protective measures :

Wear nitrile rubber gloves, gas mask and goggles.

Work in a sealed environment, local ventilation, avoid contact with oxidants/strong acids.

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