EDC.HCL CAS 25952-53-8 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride
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Chemical name: 1-(3-dimethylaminopropyl) -3-ethylcarbodiimide Hydrochloride
25952-53-8
C8H18ClN3
191.7
247-361-2
| CAS | 25952-53-8 |
| Molecular formula | C8H18ClN3 |
| Molecular weight | 191.7 |
| EIENCS | 247-361-2 |
| Form | Crystalline Powder |
| Melting point | 110-115 °C(lit.) |
| boling point | / |
| Density | 0.877 g/mL at 20 °C(lit.) |
| Solubility | H2O: soluble1 gm/10 ml, clear to very slightly hazy, colorless to very faintly yellow |
| PKA | / |
| Color | White to off-white or slightly grayish |
| Storage temp |
Chemical name: 1-(3-dimethylaminopropyl) -3-ethylcarbodiimide Hydrochloride
Molecular formula: C₈H₁₈ClN₃
Molecular weight: 191.70 g/mol
CAS Number: 25952-53-8
EINECS number: 247-361-2
Appearance: White to grayish-white crystalline powder, highly hygroscopic
Suggestion
Priority scenarios:
Biological cross-linking: The combination of Sulfo-NHS boosts efficiency to over 90%.
Pharmaceutical synthesis: Preferably with a purity of ≥99%, and avoid heavy metal residues (Pb≤20 ppm).
Risk aversion
Strictly control the temperature (0-25°C) to avoid the formation of the by-product N-acylisourea.
Emerging trends
In the development of nanomedicine carriers, the demand for targeted modification mediated by EDC is increasing by 15% annually.
For export to the European Union, REACH certification is required. When purchasing, please request the MSDS and heavy metal test report
Biological coupling and cross-linking
Protein-nucleic acid cross-linking: Activates carboxyl groups to form amide bonds, which are used for antibody labeling and immunoconjugate preparation (pH 4.0-6.0).
Peptide synthesis: As a dehydrating agent, it accelerates condensation reactions and reduces racetization (often used in combination with NHS or HOBt).
Material modification
Nanoparticle functionalization: Coupling targeted molecules (such as peptide chains) to the surface of the carrier to enhance the specificity of drug delivery.
Industrial catalysis
Polymer material crosslinking: used for the curing of epoxy resin and the improvement of the weather resistance of coatings.
Optimization of reaction conditions
pH control: The optimal activation pH is 4.5-6.0 (MES buffer), and the coupling pH is 7.2-7.5 (PBS buffer).
Inhibition of side effects: The addition of Sulfo-NHS can stabilize the intermediate and reduce the risk of hydrolysis.
Protective measures
Toxicity: Irritating to skin/respiratory equipment (R36/37/38). A gas mask and acid and alkali resistant gloves are required for operation.
Storage: Dry at -20°C, away from light. After opening, protect with nitrogen.
By-product treatment
The reaction generates ethyl -(3-dimethylaminopropyl) urea, which needs to be removed by water washing or dialysis.
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