Formamidine Acetate CAS 3473-63-0, Formamidine Acetate, CAS 3473-63-0
Formamidine acetate (CAS 3473-63-0), as a highly active formamidine salt intermediate, has both core value and operational risks:Irreplaceable medical functions: Key raw material for the synthesis of anti-tumor drugs, mature process (yield of triethyl orthoformate method > 85%);
3473-63-0
C3H8N2O2
104.11
222-442-5
| CAS | 3473-63-0 |
| Molecular formula | C3H8N2O2 |
| Molecular weight | 104.11 |
| EIENCS | 222-442-5 |
| Form | Liquid |
| Melting point | 158-161 °C |
| boling point | / |
| Density | 1.124 |
| Solubility | 832g/l |
| PKA | / |
| Color | Clear colorless to light yellow |
| Storage temp | Store below +30°C. |
Molecular formula and structure
Molecular formula: C₃H₈N₂O₂
Molecular weight: 104.11 g/mol
Structure: A salt formed by formamidine (H₂N-CH=NH) and acetic acid, it belongs to the category of strongly basic organic salts.
Appearance: White to off-white crystalline powder with a strong acetic acid odor, highly hygroscopic, and should be stored in a sealed container away from light.
Irreplaceable medical functions: Key raw material for the synthesis of anti-tumor drugs, mature process (yield of triethyl orthoformate method > 85%);
Safety bottleneck: Strong hygroscopicity + skin sensitization. Strict protection is required (nitrile gloves + dust mask).
The market is highly differentiated: The price difference between industrial grade (¥26/kg) and pharmaceutical grade (¥260/kg) is up to 10 times. Purchases should be made based on actual needs.
1. Pharmaceutical intermediates (dominant uses)
● Synthesis of anti-tumor drugs
○ The key intermediate is used for the synthesis of 4-hydroxy-5-fluoropyrimidine (an anti-tumor drug precursor), with a yield of ≥85%.
○ Participated in the synthesis of cyclohexapeptide antifungal drugs and trichloropyrimidine compounds.
● Construction of heterocyclic compounds
○ It is used as a condensing agent to synthesize pyrimidine and imidazole heterocycles, enhancing the biological activity of nitrogen-containing drugs.
2. Pesticides and Materials Science
● Pesticide intermediates: Used for the synthesis of highly effective insecticides and herbicides.
● Functional materials
○ Synthesize nitrogen-containing coordination polymers or ionic liquid precursors.
○ As an electron transport layer modifier in OLED materials (emerging application).
Health risk
● Skin irritation: May cause allergic reactions (GHS classification: Skin sensitization Category 1).
● Inhalation toxicity: Dust irritates the respiratory tract. Dust masks (N95 class) are required during operation.
Protective requirements
● Personal equipment: Nitrile gloves (thickness ≥0.11mm), goggles, anti-static clothing.
● Leakage treatment: Sand and soil adsorption followed by incineration. No discharge into water bodies (LC₅₀>100 mg/L for fish).
Storage conditions
● Seal and keep away from light, humidity <40%, temperature <25℃, and keep away from oxidants.
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