Formamidine Acetate CAS 3473-63-0
Formamidine Acetate CAS 3473-63-0Formamidine Acetate CAS 3473-63-0

Formamidine Acetate CAS 3473-63-0

Formamidine Acetate CAS 3473-63-0, Formamidine Acetate, CAS 3473-63-0

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Formamidine acetate (CAS 3473-63-0), as a highly active formamidine salt intermediate, has both core value and operational risks:Irreplaceable medical functions: Key raw material for the synthesis of anti-tumor drugs, mature process (yield of triethyl orthoformate method > 85%);

3473-63-0

C3H8N2O2

104.11

222-442-5

Formamidine Acetate CAS 3473-63-0 Information

CAS 3473-63-0
Molecular formula C3H8N2O2
Molecular weight 104.11
EIENCS 222-442-5
Form Liquid
Melting point 158-161 °C
boling point /
Density 1.124
Solubility 832g/l
PKA /
Color Clear colorless to light yellow
Storage temp Store below +30°C.

Formamidine Acetate CAS 3473-63-0

What is Formamidine Acetate CAS 3473-63-0?

Molecular formula and structure

Molecular formula: C₃H₈N₂O₂

Molecular weight: 104.11 g/mol

Structure: A salt formed by formamidine (H₂N-CH=NH) and acetic acid, it belongs to the category of strongly basic organic salts.

Appearance: White to off-white crystalline powder with a strong acetic acid odor, highly hygroscopic, and should be stored in a sealed container away from light.


Irreplaceable medical functions: Key raw material for the synthesis of anti-tumor drugs, mature process (yield of triethyl orthoformate method > 85%);

Safety bottleneck: Strong hygroscopicity + skin sensitization. Strict protection is required (nitrile gloves + dust mask).

The market is highly differentiated: The price difference between industrial grade (¥26/kg) and pharmaceutical grade (¥260/kg) is up to 10 times. Purchases should be made based on actual needs.


Formamidine Acetate CAS 3473-63-0 Use

1. Pharmaceutical intermediates (dominant uses)

 ● Synthesis of anti-tumor drugs

   ○ The key intermediate is used for the synthesis of 4-hydroxy-5-fluoropyrimidine (an anti-tumor drug precursor), with a yield of ≥85%.

   ○ Participated in the synthesis of cyclohexapeptide antifungal drugs and trichloropyrimidine compounds.

 ● Construction of heterocyclic compounds

   ○ It is used as a condensing agent to synthesize pyrimidine and imidazole heterocycles, enhancing the biological activity of nitrogen-containing drugs.

2. Pesticides and Materials Science

 ● Pesticide intermediates: Used for the synthesis of highly effective insecticides and herbicides.

 ● Functional materials

   ○ Synthesize nitrogen-containing coordination polymers or ionic liquid precursors.

   ○ As an electron transport layer modifier in OLED materials (emerging application).


Formamidine Acetate CAS 3473-63-0 safety

Health risk

 ● Skin irritation: May cause allergic reactions (GHS classification: Skin sensitization Category 1).

 ● Inhalation toxicity: Dust irritates the respiratory tract. Dust masks (N95 class) are required during operation.

Protective requirements

 ● Personal equipment: Nitrile gloves (thickness ≥0.11mm), goggles, anti-static clothing.

 ● Leakage treatment: Sand and soil adsorption followed by incineration. No discharge into water bodies (LC₅₀>100 mg/L for fish).

Storage conditions

 ● Seal and keep away from light, humidity <40%, temperature <25℃, and keep away from oxidants.


Deshangchemical Info

  • ● Comgpany name : Shandong Deshang Chemicals Co., Ltd.
  • ● Main products : Treatments, sedimentation agents, flame retardants, catalysts, matte pigments, talcum powder, PVC additives, antifreeze agents, cellulose, cleaning agents, coconut oil, hydroxyethyl, cosmetics, matte agents, betaine, disinfectants, photosensitizers, humidifying agents, blue pigments, curing agents, potassium formate, sodium formate, cyclohexanol, preservatives, grinding aids.
  • ● Date of establishment : 2022-03-11
  • ● Total Employees : 200+
  • ● Registered capital: 10000000 RMB
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