Glabridin CAS 59870-68-7, Glabridin, CAS 59870-68-7
Glicoridin (CAS 59870-68-7), as a natural multi-functional active ingredient, has both value and scarcity:Irreplaceable whitening effect: The inhibitory power of tyrosinase is 16 times that of arbutin, and it has no phototoxicity.
59870-68-7
C20H20O4
324.37
611-908-7
| CAS | 59870-68-7 |
| Molecular formula | C20H20O4 |
| Molecular weight | 324.37 |
| EIENCS | 611-908-7 |
| Form | powder |
| Melting point | 154～155℃ |
| boling point | 518.6±50.0 °C |
| Density | 1.257±0.06 g/cm3 |
| Solubility | DMSO: soluble5mg/mL, clear (warmed) |
| PKA | 9.66±0.40(Predicted) |
| Color | white to light brown |
| Storage temp | room temp |
Glicoridin (CAS 59870-68-7), as a natural multi-functional active ingredient, has both value and scarcity:
Irreplaceable whitening effect: The inhibitory power of tyrosinase is 16 times that of arbutin, and it has no phototoxicity.
Capacity bottleneck: The raw material extraction rate is only 0.01%, and the process cost is high (ton price > 700,000 yuan).
Market differentiation: The price difference between industrial grade (cosmetics) and pharmaceutical grade (research) is up to three times. When purchasing, the purpose must be clearly defined.
Molecular formula and structure
Molecular formula: C₂₀H₂₀O₄
Molecular weight: 324.37 g/mol
Chemical name: 4 - [(3 r) - 8, 8 - dimethyl - 3, 4 - dihydro - 2 h, 8 h - pyran and olefinic [2, 3 - f] color - 3 - base] - 1, 3 - benzodiazepines
Structure: Isoflavan flavonoids, containing benzopyran rings and hydroquinone groups
Appearance: White to off-white crystalline powder (high purity ≥98%), low purity (10%-40%) pale yellow or brown
1. Cosmetics (dominating the market, accounting for more than 60%
● Whitening mechanism: Inhibits tyrosinase activity, reduces melanin production, and the effect is mild and non-irritating.
○ Recommended concentration: 0.001%-3% (Patent recommendation: 0.0007%-0.05% for tanning).
● Anti-aging repair
○ It can eliminate free radicals and has better antioxidant efficacy than glutathione.
○ Promote collagen synthesis and reduce wrinkles (clinically verified).
● Brand application: Core ingredients of high-end skin care products such as Lancome and Chanel.
2. Pharmaceuticals and health products
● Anti-inflammatory and immune regulation: Inhibits inflammatory factors (TNF-α, IL-6), alleviates acne and eczema.
● Anti-tumor potential: Induces apoptosis of cervical cancer Hela cells and inhibits proliferation of colorectal cancer cells (in vitro study).
● Food additives: As antioxidants in functional beverages/health products, the dosage must comply with GB standards.
3. Emerging fields
● Textile industry: Exploring as an antibacterial finishing agent (Research stage).
● Chemical raw materials: Synthesis of high value-added derivatives (such as antioxidant ionic liquids).
● Health risk
○ Skin irritation: High concentration (> 3%) may cause sensitization and local testing is required.
○ Intake contraindications: Excessive intake can lead to potassium loss and elevated blood pressure (daily intake is recommended to be ≤3 mg).
● Storage and Operation
○ Conditions: 2-8℃, sealed and protected from light, humidity < 60% (HPLC standards require -20℃).
○ Protection: Wear nitrile gloves and a dust mask (N95 grade) during operation.
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