Imidazole CAS 288-32-4, Imidazole, CAS 288-32-4
Chemical structure: A five-membered heterocyclic structure containing two meta-nitrogen atoms (nitrogen No. 1 is acidic and nitrogen No. 3 is basic), forming an amphoteric ionic structure.
288-32-4
C3H4N2
333.33861
206-019-2
| CAS | 288-32-4 |
| Molecular formula | C3H4N2 |
| Molecular weight | 333.33861 |
| EIENCS | 206-019-2 |
| Form | / |
| Melting point | / |
| boling point | / |
| Density | / |
| Solubility | Dissolves slowly in water to form a viscous solution; insoluble in ethanol and in ether. |
| PKA | / |
| Color | White to yellow powder |
| Storage temp | / |
Structure and Characteristics
Chemical structure: A five-membered heterocyclic structure containing two meta-nitrogen atoms (nitrogen No. 1 is acidic and nitrogen No. 3 is basic), forming an amphoteric ionic structure.
Solubility: Readily soluble in water, ethanol and acetone; Slightly soluble in benzene and petroleum ether.
Stability: Stable at room temperature, but decomposes in strong acids (releasing HCN), and may explode in contact with oxidants.
Spectrum and Parameters
Ultraviolet absorption: λₘ ₘ =210 nm (purity detection index).
Specific rotation: Monoclinic crystal system, intermolecular hydrogen bonds stabilize the lattice.
Pharmaceutical synthesis
Antifungal drugs: Synthetic ketoconazole, clotrimazole, miconazole and other core mother nuclei.
Anti-cancer adjuvant: As a histidine analogue, it participates in the simulation of enzyme active centers.
Industry and Materials
Epoxy resin curing agent: Dosage: 4 to 8 parts, enhancing mechanical strength and heat resistance (heat distortion temperature: 117-166°C).
Metal corrosion inhibitor: Protects the copper layer of printed circuit boards and inhibits oxidation.
Electronic chemicals: Semiconductor photoresist additives (purity ≥99.99%, unit price over 500,000 yuan per ton).
Agriculture and biotechnology
Synthesis of fungicides: Production of fruit and vegetable preservatives such as imazalil and imazalil.
Protein purification: Competitively bind Ni²⁺ and elute His-Tag fusion protein.
Organic synthesis catalysis
Condensing agent: Carbonyl diimidazole (CDI) promotes the formation of amide bonds.
Silane ether protection: Catalyzes the tert-butyl dimethyl silane etherification reaction.
Toxicity data
Acute toxicity: Oral LD₅₀=18.80 mg/kg in mice, oral LD₅₀=610 mg/kg in rats.
Health risks: Skin erosion (Category 1B), eye damage (Category 1), liver and kidney damage caused by long-term exposure.
Protection and Emergency Response
Operating equipment: Gas mask, nitrile gloves, anti-corrosion suit, fume hood operation.
Leakage treatment: After adsorption with sand and soil, incinerate. Do not flush with water (to prevent diffusion).
Storage conditions: Sealed and protected from light, ≤25°C, away from strong acids/oxidants.
Transport marking
UN 3263 (Class 6.1 Toxic substances, Class 8 Corrosives).
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