Imidazole CAS 288-32-4
Imidazole CAS 288-32-4Imidazole CAS 288-32-4

Imidazole CAS 288-32-4

Imidazole CAS 288-32-4, Imidazole, CAS 288-32-4

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Chemical structure: A five-membered heterocyclic structure containing two meta-nitrogen atoms (nitrogen No. 1 is acidic and nitrogen No. 3 is basic), forming an amphoteric ionic structure.

288-32-4

C3H4N2

333.33861

206-019-2

Imidazole CAS 288-32-4 Information

CAS 288-32-4
Molecular formula C3H4N2
Molecular weight 333.33861
EIENCS 206-019-2
Form /
Melting point /
boling point /
Density /
Solubility Dissolves slowly in water to form a viscous solution; insoluble in ethanol and in ether.
PKA /
Color White to yellow powder
Storage temp /

Imidazole CAS 288-32-4

What is Imidazole CAS 288-32-4?

Structure and Characteristics

Chemical structure: A five-membered heterocyclic structure containing two meta-nitrogen atoms (nitrogen No. 1 is acidic and nitrogen No. 3 is basic), forming an amphoteric ionic structure.

Solubility: Readily soluble in water, ethanol and acetone; Slightly soluble in benzene and petroleum ether.

Stability: Stable at room temperature, but decomposes in strong acids (releasing HCN), and may explode in contact with oxidants.

Spectrum and Parameters

Ultraviolet absorption: λₘ ₘ =210 nm (purity detection index).

Specific rotation: Monoclinic crystal system, intermolecular hydrogen bonds stabilize the lattice.


Imidazole CAS 288-32-4 Use

Pharmaceutical synthesis

Antifungal drugs: Synthetic ketoconazole, clotrimazole, miconazole and other core mother nuclei.

Anti-cancer adjuvant: As a histidine analogue, it participates in the simulation of enzyme active centers.

Industry and Materials

Epoxy resin curing agent: Dosage: 4 to 8 parts, enhancing mechanical strength and heat resistance (heat distortion temperature: 117-166°C).

Metal corrosion inhibitor: Protects the copper layer of printed circuit boards and inhibits oxidation.

Electronic chemicals: Semiconductor photoresist additives (purity ≥99.99%, unit price over 500,000 yuan per ton).

Agriculture and biotechnology

Synthesis of fungicides: Production of fruit and vegetable preservatives such as imazalil and imazalil.

Protein purification: Competitively bind Ni²⁺ and elute His-Tag fusion protein.

Organic synthesis catalysis

Condensing agent: Carbonyl diimidazole (CDI) promotes the formation of amide bonds.

Silane ether protection: Catalyzes the tert-butyl dimethyl silane etherification reaction.


Imidazole CAS 288-32-4 safety

Toxicity data

Acute toxicity: Oral LD₅₀=18.80 mg/kg in mice, oral LD₅₀=610 mg/kg in rats.

Health risks: Skin erosion (Category 1B), eye damage (Category 1), liver and kidney damage caused by long-term exposure.

Protection and Emergency Response

Operating equipment: Gas mask, nitrile gloves, anti-corrosion suit, fume hood operation.

Leakage treatment: After adsorption with sand and soil, incinerate. Do not flush with water (to prevent diffusion).

Storage conditions: Sealed and protected from light, ≤25°C, away from strong acids/oxidants.

Transport marking

UN 3263 (Class 6.1 Toxic substances, Class 8 Corrosives).


Deshangchemical Info

  • ● Comgpany name : Shandong Deshang Chemicals Co., Ltd.
  • ● Main products : Treatments, sedimentation agents, flame retardants, catalysts, matte pigments, talcum powder, PVC additives, antifreeze agents, cellulose, cleaning agents, coconut oil, hydroxyethyl, cosmetics, matte agents, betaine, disinfectants, photosensitizers, humidifying agents, blue pigments, curing agents, potassium formate, sodium formate, cyclohexanol, preservatives, grinding aids.
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