Imidazole CAS 288-32-4, Imidazole, CAS 288-32-4
CAS : 288-32-4
Formula : C3H4N2
Mol. wt. : 333.33861
EINECS : 206-019-2
| CAS | 288-32-4 |
| Molecular formula | C3H4N2 |
| Molecular weight | 333.33861 |
| EIENCS | 206-019-2 |
| Form | Crystalline powder |
| Melting point | 88–91 ℃ |
| boling point | 257 ℃ |
| Density | 1.0303 g/cm³ (20℃) |
| Solubility | Dissolves slowly in water to form a viscous solution; insoluble in ethanol and in ether. |
| PKA | / |
| Color | White to yellow powder |
| Storage temp |
Chemical Name: Imidazole (Also known as: Glyoxane, 1, 3-diazole, m-diazole)
Molecular formula: C₃H₄N₂
Molecular weight: 68.08 g/mol
CAS Number: 288-32-4
EINECS number: 206-019-2
Appearance: White to light yellow crystalline powder (industrial products may be slightly yellow), with a faint amine odor
Solubility: Readily soluble in water, ethanol, acetone, ether and chloroform; Slightly soluble in benzene and poorly soluble in petroleum ether
Usage suggestions
Level selection:
Industrial grade (99%) : Resin curing, rust inhibitor.
High purity grade (≥99.5%) : For pharmaceutical synthesis, a heavy metal report (Pb≤1 ppm) is required.
Operation optimization
The reactivity is higher in an acidic environment (pH<3). It is recommended to be compounded with citric acid to enhance the effect.
Alternative trend:
Develop bio-based imidazole analogues (such as histidine derivatives) to reduce environmental toxicity.
Pharmaceutical synthesis (Dominant use)
Antifungal drugs: Synthetic clotrimazole, miconazole, ketoconazole, etc., accounting for 40% of the global demand for pharmaceutical intermediates.
Cardiovascular drugs: As a key intermediate for hypoglycemic treatment drugs and artificial plasma.
Industrial materials
Epoxy resin curing agent: Enhances the mechanical strength, insulation and chemical resistance of products, and is used in electrical appliances and automotive paints.
Copper anti-rust agent: Surface treatment of printed circuit boards to prevent oxidation and corrosion.
Agriculture and daily chemicals
Pesticide enhancers: Enhance the penetration of boric acid preparations and insecticides.
Preservative and antiseptic: Used for fruit preservation to extend the shelf life.
Emerging fields
Electronic chemicals: Electrolyte additives for lithium-ion batteries, enhancing electrode stability.
Biodegradable materials: Participate in the synthesis of environmentally friendly polymer crosslinking agents.
Health risk:
Toxicity: Oral LD₅₀ in rats was 18.8 mg/kg, and skin contact caused inflammation (R34).
Chronic hazards: Long-term exposure may damage the mucous membranes. When operating, wear a gas mask and acid and alkali resistant gloves.
Storage and transportation
Cool and well-ventilated (≤25℃), relative humidity <75%, away from light and sealed.
Incompatible substances: Strong oxidants (such as nitric acid), halogenated hydrocarbons (causing violent reactions).
Environmental protection compliance
Export requires REACH certification; The wastewater containing nitrogen needs to be treated to meet the standards (COD≤100 mg/L).
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