Kojic acid CAS 501-30-4

Kojic acid CAS 501-30-4 Information

CAS	501-30-4
Molecular formula	C6H6O4
Molecular weight	142.11
EIENCS	207-922-4
Form	Crystalline Powder
Melting point	152-155 °C (lit.)
boling point	179.65°C (rough estimate)
Density	1.1712 (rough estimate)
Solubility	DMSO (Slightly), Methanol (Slightly, Sonicated)
PKA	7.9(at 25℃)
Color	White to beige-brown
Storage temp	Store below +30°C.

What is Kojic acid CAS 501-30-4?

Kojic acid (CAS 501-30-4), as a multi-domain functional compound, has the following core values and usage suggestions:

Efficacy advantages:

Whitening benchmark: Low concentration effectively inhibits melanin, compound system enhances stability;

Green anti-corrosion: It replaces nitrite and has both color protection and antibacterial functions.

Safety boundary:

The addition amount of cosmetics should be ≤1% to avoid the risk of high-concentration sensitization.

Food applications must strictly comply with GB limits (for example, smoked meat ≤0.6%).

Industry trend

Upgrade of biological fermentation technology: Gene-edited strains increase yield and reduce production costs;

Derivative development: Kojic acid dipalmitate (cosmetic grade) enhances light stability.

Kojic acid CAS 501-30-4 Use

Cosmetics (Core ingredients for whitening)

Mechanism of action: Chelates the copper ions of tyrosinase and inhibits melanin production (0.00142% concentration can inhibit 50% of the enzyme activity).

Application form:

Addition concentration: 0.1-1% (safety limit for resident products), combined with SOD and plant extracts for enhanced efficacy.

Product types: Whitening essence, Sunscreen, freckle-removing Mask (effective for freckles and chloasma).

2. Food Industry (Preservatives and antiseptic agents)

Preservative: Broad-spectrum antibacterial (stronger than sodium benzoate), wide pH tolerance, thermal stability, 0.1-0.6%.

Preservative: Inhibits enzymatic Browning of fruits and vegetables (such as apples and mushrooms soaked in 0.1% solution), delays the loss of vitamin C, treated with 0.1% solution.

Color development and protection agent: Replace sodium nitrite to maintain the color of smoked meat, inhibit the formation of nitrosamine carcinogens, 0.25-0.6%.

3. Medicine and Agriculture

Medicine

Anti-inflammatory: Inhibits hyaluronidase (inhibition rate 86.9% at 0.1% concentration).

Anti-cancer potential: As an antifungal sensitizer, it reduces the dosage of chemotherapy drugs.

Agriculture: Biopesticides: Chelate insect phenol oxidase Cu²⁺ to kill diamondback moth and cotton bollworm.

Yield-increasing micro-fertilizer: 0.5% - 1.0% foliar spraying promotes root development and increases the fresh weight of vegetables by 100%.

Kojic acid CAS 501-30-4 safety

1. Carcinogenicity doubts

WHO classification: Group 3 Carcinogens (Insufficient evidence to classify).

Experimental conclusion:

Long-term oral administration of high doses (> 1%) in mice may induce thyroid tumors, but there is no clinical evidence in humans.

Oral LD₅₀ in rats was > 5,000 mg/kg (actually non-toxic).

Deshangchemical Info

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