kojic acid CAS 501-30-4, kojic acid CAS 501-30-4
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Kojic acid CAS 501-30-4 Inhibit tyrosinase activity (inhibition rate 50% at 100 μmol/L) and block melanin production
501-30-4
C6H6O4
142.11
207-922-4
| CAS | 501-30-4 |
| Molecular formula | C6H6O4 |
| Molecular weight | 142.11 |
| EIENCS | 207-922-4 |
| Form | / |
| Melting point | 152-155 °C (lit.) |
| boling point | 179.65°C (rough estimate) |
| Density | 1.1712 (rough estimate) |
| Solubility | DMSO (Slightly), Methanol (Slightly, Sonicated) |
| PKA | 7.9(at 25℃) |
| Color | White to beige-brown |
| Storage temp | Store below +30°C. |
Appearance: Crystalline powder, with a color ranging from white to beige or yellowish-brown
Density: Approximately 1.1712 (estimated value) 1.5 + / - 0.1 g/cm after
Melting point: 152-155°C (Reported in literature)
Boiling point: 401.7°C (760mmHg) 179.65°C (estimated value)
Flash point: 179.9°C
Refractive index: 1.4434 (estimated value)
Water solubility: Readily soluble in water, alcohol and acetone; Slightly soluble in ether, ethyl acetate, chloroform and pyridine; Benzene insoluble
Solubility: Slightly soluble in DMSO and slightly soluble in methanol (ultrasonic treatment required)
Acidity coefficient: 7.9 (25℃)
Stability: Stable, but unstable when exposed to light and heat
Other properties: It turns red when reacting with ferric chloride and can reduce Ferrin's reagent and silver nitrate ammonia
Cosmetics and personal care
Whitening and removing spots
Inhibit tyrosinase activity (inhibition rate 50% at 100 μmol/L) and block melanin production.
Common concentration: 0.5% - 2% (for face cream and essence). Caution is needed for high concentrations.
Antioxidant: Scavenging free radicals (scavenging rate at 1mg/mL: 30.2% superoxide free radicals, 36.4% singlet oxygen).
Anti-inflammatory and soothing: Inhibits hyaluronidase (0.1% inhibition rate 86.9%).
2. Food industry
Anti-corrosion and preservation
It has stronger antibacterial properties than sodium benzoate and a wide pH range of application.
It is used for the preservation of fruits and vegetables (soaking in 0.1% solution to prevent Browning) and the color protection of meat.
Antioxidants: Prevent oil rancidity and work in synergy with vitamin C.
3. Medicine and Agriculture
Medicine: Antifungal, anti-inflammatory and analgesic, with potential anti-cancer effects (further research is needed).
Agriculture
Biological pesticides (inhibiting phenol oxidase in insects).
Plant growth promoters (increase production by 10% - 15%).
Toxicity controversy
WHO Group 3 carcinogens (possibly carcinogenic to humans), but animal experiments have not confirmed their tumorigenicity.
Thyroid effect: High-dose oral administration may inhibit iodine absorption (rodent experiment).
Regulation of various countries
China: Included in the "Catalogue of Used Cosmetic Ingredients" (2021 Edition), with no limit regulations, it is recommended to be ≤1%.
Japan: It was banned in 2003 and lifted in 2005, with a usage limit of 0.1% to 1%.
Eu/US: It is considered safe to add ≤1% to resident products.
Usage Warning:
High concentrations (> 2%) may cause sensitization and contact dermatitis.
Avoid inhaling dust during operation. If it gets into the eyes, rinse immediately.
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