Melatonine CAS 73-31-4
Melatonine CAS 73-31-4Melatonine CAS 73-31-4

Melatonine CAS 73-31-4

Melatonine CAS 73-31-4, Melatonine, CAS 73-31-4

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Melatonin (CAS 73-31-4), as the core substance for endogenous sleep regulation, its value and risks need to be scientifically weighed:Irreplaceable physiological functions: Precisely regulate the circadian rhythm, and a small dose (0.5-3 mg) can improve sleep efficiency.

73-31-4

C13H16N2O2

232.28

200-797-7

Melatonine CAS 73-31-4 Information

CAS 73-31-4
Molecular formula C13H16N2O2
Molecular weight 232.28
EIENCS 200-797-7
Form Powder
Melting point 116.5-118 °C
boling point 374.44°C
Density 1.1099
Solubility Soluble in ethanol to at least 50mg/ml
PKA 16.26±0.46(Predicted)
Color white to off-white
Storage temp -20°C

Melatonine CAS 73-31-4

What is Melatonine CAS 73-31-4?

1. Biosynthetic pathways

Raw materials: L-tryptophan → 5-hydroxytryptophan → 5-hydroxytryptamine → N-acetyl-5-hydroxytryptamine → Melatonin.

Regulatory mechanism

Controlled by photoperiod, the dark environment stimulates the secretion of the pineal gland. The concentration at night is 5 to 10 times higher than that during the day, with the peak occurring between 2 and 4 a.m.

Age influence: After the age of 35, the secretion volume decreases by 10-15% every 10 years, and the rhythm disappears in old age.

2. Core physiological functions

Regulating the circadian rhythm: By activating the MT1/MT2 receptors in the brain, it inhibits neuronal discharge and promotes the synchronization of the sleep-wake cycle.

Antioxidant effect: Eliminates free radicals and protects cells from oxidative damage (more effective than glutathione).

Immune regulation: Enhance NK cell activity and inhibit the release of inflammatory factors.


Melatonin (CAS 73-31-4), as the core substance for endogenous sleep regulation, its value and risks need to be scientifically weighed:

Irreplaceable physiological functions: Precisely regulate the circadian rhythm, and a small dose (0.5-3 mg) can improve sleep efficiency.

Clear safety boundary: High safety in short-term use, but excessive inhibition of gonadal development in the long term (R60 risk marker);

Emerging markets explode: Aging and the sleep economy drive the demand for health supplements to increase by more than 10% annually.


Melatonine CAS 73-31-4 Use

1. Treatment of sleep disorders (leading application

 ● Shorten the time to fall asleep: Oral administration of 0.5 to 5 mg can reduce the average time to fall asleep by 7 minutes and extend the total sleep time by 8 minutes.

 ● Applicable population

   ○ Jet lag syndrome (take before going to bed after crossing 5+ time zones)

   ○ Insomnia in middle-aged and elderly people (those over 55 years old with atrophy of the pineal gland)

   ○ Sleep disorders in children (requiring doctor's guidance).


2. Other medical and health applications

 ● Anti-aging: Inhibits the production of glucocorticoids and delays cellular aging.

 ● Skin whitening: Inhibits melanin production, used in whitening cosmetics (addition amount 0.1-1%).

 ● Neuroprotection: Alleviates hypoxic-ischemic brain injury and reduces the apoptosis rate of neurons.


3. Food and health products

 ● Dietary supplements: In China, the daily intake is stipulated to be 1 to 3 mg, used to regulate sleep (such as the main component of "Brain Platinum").

 ● Natural sources: sour cherries, walnuts, tomatoes (walnuts have the highest content).


Melatonine CAS 73-31-4 safety

1. Toxicity data

  • Acute toxicity:Rat oral LD₅₀ > 3200 mg/kg (actually non-toxic).

  • Long-term safety:

    • Short-term (≤4 weeks) adverse reaction rate < 3%, including drowsiness, dizziness and headache;

    • Long-term high-dose (> 10 mg per day may inhibit gonadal development and lower body temperature.

2. People who should avoid or use with caution

CrowdRisk

Pregnant and lactating women

Hormones interfere with fetal development

Patients with autoimmune diseases

It may activate an immune response

Patients with depression

Aggravate emotional disorders

Teenagers

Inhibitory sexual maturity (insufficient evidence but caution is needed)

3. Operation and Storage

  • Protective requirements:Wear gloves/goggles when operating to avoid inhaling dust.

  • Waste liquid treatment:Adsorbed with sand and then burned, prohibited discharge into water bodies (for fish) LC₅₀ > 1000 mg/L.


Deshangchemical Info

  • ● Comgpany name : Shandong Deshang Chemicals Co., Ltd.
  • ● Main products : Treatments, sedimentation agents, flame retardants, catalysts, matte pigments, talcum powder, PVC additives, antifreeze agents, cellulose, cleaning agents, coconut oil, hydroxyethyl, cosmetics, matte agents, betaine, disinfectants, photosensitizers, humidifying agents, blue pigments, curing agents, potassium formate, sodium formate, cyclohexanol, preservatives, grinding aids.
  • ● Date of establishment : 2022-03-11
  • ● Total Employees : 200+
  • ● Registered capital: 10000000 RMB
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