N-Bromosuccinimide CAS 128-08-5, N-Bromosuccinimide, CAS 128-08-5
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N-bromosuccinimide (CAS 128-08-5) is an irreplaceable bromination/oxidation reagent in organic synthesis. Its core characteristics include:High selectivity: Precise bromination of weak C-H bonds, suitable for the synthesis of drugs and pesticides;
128-08-5
C4H4BrNO2
177.98
204-877-2
| CAS | 128-08-5 |
| Molecular formula | C4H4BrNO2 |
| Molecular weight | 177.98 |
| EIENCS | 204-877-2 |
| Form | Crystalline Powder |
| Melting point | 175-180 °C (dec.)(lit.) |
| boling point | 221.4°C (rough estimate) |
| Density | 2.098 |
| Solubility | 14.8g/l (decomposition) |
| PKA | -2.78±0.20(Predicted) |
| Color | White to light yellow |
| Storage temp |
N-bromosuccinimide (CAS 128-08-5) is an irreplaceable bromination/oxidation reagent in organic synthesis. Its core characteristics include:
High selectivity: Precise bromination of weak C-H bonds, suitable for the synthesis of drugs and pesticides;
Versatility: It has the functions of oxidation, preservation and material modification.
High-risk operations: Strong corrosiveness and explosion risks require strict protection.
The market classification is clear: High-purity reagents for scientific research are expensive, while industrial-grade reagents can be customized in bulk
Key reagents for organic synthesis
Bromination reaction
Selective allyl bromide/benzyl hydrogen (Wohl-Ziegler reaction)
Synthesize pharmaceutical intermediates (such as antibiotics, vitamin D₃) and pesticides (thiabendazole).
Oxidation reaction
Alcohol → aldehyde/ketone, aldehyde → carboxylic acid;
Silicon-based ethers are aldehydes in the presence of AIBN.
Industrial and functional materials
Preservation and anti-corrosion: Fruit preservatives, mold inhibitors;
Polymer additives: Rubber processing, flame-retardant polymer synthesis;
Biochemical analysis: Tryptophan modification, ascorbic acid determination.
Health risk
Irritation: Strongly corrosive to skin, eyes and mucous membranes. Contact can cause burns (R34/R35).
Toxicity: The LD₅₀ in the abdominal cavity of mice was 153 mg/kg (highly toxic); Long-term exposure can cause dermatitis or respiratory tract damage.
Protective measures: During operation, a gas mask, corrosion-resistant gloves, goggles and protective clothing must be worn.
Environmental and operational risks
Highly toxic to aquatic organisms (R50), strictly prohibited from being discharged into water bodies.
Explosion risk: Contact with aniline, hydrazine hydrate and peroxides may cause explosion. It should be stored separately
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