N-Methyl-2-Pyrrolidone CAS 872-50-4

N-Methyl-2-Pyrrolidone CAS 872-50-4 Information

CAS	872-50-4
Molecular formula	C5H9NO
Molecular weight	99.13
EIENCS	212-828-1
Form	Liquid
Melting point	-24 °C (lit.)
boling point	202 °C (lit.) 81-82 °C/10 mmHg (lit.)
Density	1.028 g/mL at 25 °C (lit.)
Solubility	>=10 g/100 mL at 20 ºC
PKA	-0.41±0.20(Predicted)
Color	≤20(APHA)
Storage temp	Store at +5°C to +30°C.

What is N-Methyl-2-Pyrrolidone CAS 872-50-4?

NMP, due to its high dissolving power, low toxicity and thermal stability, has become the core solvent for lithium batteries, semiconductors and high-end polymers. However, its reproductive toxicity risk and the increasingly strict EU regulations have driven the industry to shift towards recycling technologies and green alternatives. Future research and development should focus on: 

Toxicity mechanism research: Clarify the pathological pathway of chronic exposure;

Closed-loop process optimization: Increase recovery efficiency to over 95%;

Biobased substitutes development: Such as lactate ester solvents

Packaging and Storage

Packaging: Galvanized iron drums (50 - 100 kg) or glass bottles (protected from light), sealed with inert gas.

Storage: Cool and ventilated (< 30°C), away from fire sources, oxidants, and prevent static electricity accumulation. Leakage handling: Collect using electrostatic vacuum equipment and dispose as hazardous waste.

N-Methyl-2-Pyrrolidone CAS 872-50-4 Use

1. Electronics and New Energy

Lithium batteries: Used as the coating solvent for electrodes (such as PVDF binder), improving electrode uniformity and battery energy density.

Semiconductor manufacturing: Cleaning photoresist, removing impurities on the wafer surface (replacing more toxic DMF or DMSO). 

2. Chemical Engineering and Materials

Polymer Synthesis: Dissolve difficult-to-dissolve engineering plastics such as polyimide (PI) and polyphenylene sulfide (PPS) as the reaction medium.

Extraction and Separation:

Aromatics purification (such as ethylbenzene and xylene)

Natural gas desulfurization (selective absorption of H₂S). 

3. Medicine and Pesticides

Medicine solvents: Reaction medium for synthesizing antibiotics and vaccine adjuvants.

Pesticide additives: Enhance the penetration of herbicides (note the risk of skin contact). 

4. Environmental Protection and Cleaning 

Industrial cleaning agents: Desmearing (aircraft coating), degreasing (precision instruments), which can be recycled and reused.

Environmental alternatives: Due to their strong biodegradability, they are gradually replacing harmful solvents such as dichloromethane.

N-Methyl-2-Pyrrolidone CAS 872-50-4 safety

Health risks

Acute toxicity: LD₅₀ for rats via oral route = 3914 - 7900 mg/kg (low toxicity), but high concentration inhalation can irritate the respiratory tract.

Chronic exposure: Long-term exposure may cause central nervous system damage and reproductive toxicity (EU warning may affect fertility).

Personal protection: Must wear a respirator (EN14387 standard) and permeation-resistant gloves (butyl rubber).

Environment and regulations

Limit value standards: Permissible concentration in the workplace 100 mg/m³ (China/Europe). Waste liquid treatment: Vacuum depressurization recovery technology (recovery rate > 90%), avoiding direct discharge

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