N,N-Dimethylacetamide CAS 127-19-5, N,N-Dimethylacetamide, CAS 127-19-5
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N, N-dimethylacetamide (CAS 127-19-5) is a strongly polar aprotic solvent, and its core characteristics include:Strong solubility: covering three major fields including synthetic fibers, medicine, and polymer materials.
127-19-5
C4H9NO
87.12
204-826-4
| CAS | 127-19-5 |
| Molecular formula | C4H9NO |
| Molecular weight | 87.12 |
| EIENCS | 204-826-4 |
| Form | Liquid |
| Melting point | -20 °C (lit.) |
| boling point | 164.5-166 °C (lit.) |
| Density | 0.937 g/mL at 25 °C (lit.) |
| Solubility | >1000g/l soluble |
| PKA | / |
| Color | Colorless and transparent liquid |
| Storage temp |
N, N-dimethylacetamide (CAS 127-19-5) is a strongly polar aprotic solvent, and its core characteristics include:
Strong solubility: covering three major fields including synthetic fibers, medicine, and polymer materials;
Controllable toxicity: Low acute toxicity but skin absorption must be prevented. Protective measures during operation are indispensable.
Mature process: The acetic anhydride method is dominant, while the acetic acid method has become a new trend due to cost-effectiveness.
Market classification: Industrial-grade with high cost performance (¥80/kg), research-grade purity preferred (> ¥7/g)
Industrial solvents (core uses)
Synthetic fibers: acrylonitrile dry spinning, polyurethane resin solvent.
Pharmaceuticals/Pesticides: Intermediates for synthetic antibiotics (such as sulfonamides) and insecticides.
Chemical catalysis
Accelerate cyclization and halogenation reactions, and be used as an electrolytic solvent and paint remover.
Polymer materials
It is used as an extraction solvent for the production of polyamide films and coatings, and for the separation of styrene.
Health risk
Acute toxicity: The oral LD₅₀ in rats was 3.59 g/kg (low toxicity), but it could be absorbed through the skin.
Irritation: Strongly irritates the eyes, skin and mucous membranes. Rinse with plenty of water after contact.
Chronic effects: Long-term exposure can lead to liver necrosis and testicular atrophy, and contact during pregnancy may cause teratogenicity.
Protective requirements: During operation, a gas mask, corrosion-resistant gloves and goggles must be worn.
Environmental and operational risks
Flammability: Explosion limit 1.8% - 11.5% (volume), flash point 70 ℃. Keep away from fire sources.
Environmental toxicity: Highly toxic to aquatic organisms (R50). Discharge is strictly prohibited.
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