Nuciferine CAS 475-83-2 Information
| CAS |
475-83-2 |
| Molecular formula |
C₁₉H₂₁NO₂ |
| Molecular weight |
295.38 |
| EIENCS |
618-170-5 |
| Form |
powder |
| Melting point |
165.5°C |
| boling point |
437.06°C (rough estimate) |
| Density |
1.1156 (rough estimate) |
| Solubility |
|
| PKA |
/ |
| Color |
/ |
| Storage temp |
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What is Nuciferine CAS 475-83-2?
Nuciferine (CAS 475-83-2) is a multifunctional alkaloid from lotus leaves with broad therapeutic potential in metabolic disorders (diabetes, hyperlipidemia), cancer cachexia, inflammation, and neuroprotection. Its mechanisms involve dual modulation of serotonin/dopamine receptors, ferroptosis inhibition, and GLUT4/AMPK activation. While commercially available for research (purity up to 99.71%), challenges like solubility and comprehensive toxicity profiles require further optimization
. For therapeutic use, prioritize pharmaceutical-grade material (≥98%) and monitor CYP2D6 interactions clinically.
Nuciferine CAS 475-83-2 Use
Key Targets:
Serotonin Receptors:
Antagonist of 5-HT₂c (IC₅₀=131 nM), 5-HT₂A (IC₅₀=478 nM), 5-HT₂B (IC₅₀=1 μM) .
Inverse agonist of 5-HT₇ (IC₅₀=150 nM) .
Dopamine Receptors: Partial agonist of D₂ (EC₅₀=64 nM) .
Pharmacological Effects:
Anticancer & Anti-Cachexia:
Binds directly to HSP90AA1, activating AKT-mTOR and suppressing NF-κB pathways to reduce muscle atrophy in cancer cachexia .
In mice, 10 mg/kg nuciferine improved grip strength by 29.7% and reduced degradation of muscle proteins (Atrogin1/MuRF1) .
Antidiabetic:
Enhances GLUT4 translocation via AMPK and PKC pathways, boosting glucose uptake in L6 cells by 2.8-fold .
Reverses liver steatosis and pancreatic islet hypertrophy in diabetic mice .
Anti-Inflammatory:
Inhibits NF-κB activation by degrading IκB-α in LPS-stimulated RAW264.7 cells, dependent on PPAR pathways .
Otoprotection:
At 90 μM, protects cochlear hair cells from cisplatin-induced ferroptosis by inhibiting NCOA4-mediated ferritinophagy .
Antipsychotic Potential:
Blocks 5-HT₂A agonist effects, rescues PCP-induced behavioral disruptions in rodents without catalepsy .
Nuciferine CAS 475-83-2 safety
Acute Toxicity:
Rat oral LD₅₀: 280 mg/kg .
Low skin irritation (rabbit dermal LD₅₀ >5000 mg/kg) .
Drug Interactions:
Inhibits CYP2D6, caution with anti-arrhythmia drugs (e.g., amiodarone, metoprolol) .
Side Effects:
High doses may cause minor cytotoxicity or reversible peripheral neuropathy .
