Proglumide CAS 6620-60-6 Uses
In in-depth research in the medical field, the substance alanine has been fully proven to be a δ -opioid agonist. In the process of complex physiological mechanisms and pharmacological effects, this characteristic it possesses plays an important role, especially in analgesia, and may have a non-negligible contribution to its overall analgesic effect.
From the perspective of its chemical properties and mechanism of action, it is a non-peptide oral active cholecystokinin (CCK) -a /B receptor antagonist. This means that after entering the human body, it can bind to the receptor related to cholecystokinin in a specific way, thereby exerting the corresponding physiological regulatory effect.
Specifically in terms of drug application, propylamine (with mild pharmacological effects) is a drug used in clinical practice for specific therapeutic purposes. Its main mechanism of action lies in its ability to effectively inhibit gastrointestinal peristalsis, rationally regulate the movement rhythm of the gastrointestinal tract, and prevent excessive peristalsis from causing discomfort to patients. At the same time, it can also reduce the secretion of gastric juice, which is of great significance for maintaining the acid-base balance in the gastrointestinal tract and protecting the mucosa.
As a cholecystokinin antagonist, the role of proglumide is very crucial. It can precisely block the CCKA and CCKB subtypes. Through this specific blocking effect, it regulates the physiological effects of cholecystokinin in the body. In clinical treatment, it was once mainly used to treat the disease of gastric ulcer. In the medical environment at that time, it brought hope of alleviating the pain to many patients with gastric ulcers. However, with the continuous deepening of medical research and the increasing progress of drug development technology, it has now been replaced by a series of more advantageous new drugs.
In addition, acrylamide also shows selective blocking of the effect of CCK on the central nervous system in terms of its mechanism of action. This selective blocking ability enables it to effectively intervene in the related effects of CCK in the central nervous system without affecting other normal physiological functions.
It is worth mentioning that proglutamide also has important pharmacological effects. It has the function of inhibiting gastric juice secretion and can form a protective regulatory mechanism in the gastric environment, reducing the irritation of digestive juices such as gastric acid to the gastric mucosa. At the same time, it can also protect the mucosa of the stomach and duodenum, enhance the barrier function of the mucosa, and prevent harmful substances from causing damage to the mucosa. In addition, alanine also has antiepileptic and antioxidant activities, which makes it have certain research value and application potential in the fields of neurological diseases and antioxidance-related treatments
