Propionyl Bromide CAS 598-22-1 Information
| CAS |
598-22-1 |
| Molecular formula |
C3H5BrO |
| Molecular weight |
136.98 |
| EIENCS |
209-924-0 |
| Form |
Tablets |
| Melting point |
/ |
| boling point |
103-104 °C (lit.) |
| Density |
1.521 g/mL at 25 °C (lit.) |
| Solubility |
/ |
| PKA |
/ |
| Color |
Gray-bluish |
| Storage temp |
|
What is Propionyl Bromide CAS 598-22-1?
Propionyl bromide (CAS 598-22-1) is a highly active but high-risk acyl halide reagent:
Synthesis criticality: An irreplaceable intermediate for the synthesis of pharmaceuticals and polymer materials, with strong reactivity.
High-risk operation: Strong corrosion, flammable, explosive upon contact with water. Strict protection is required. Storage should be protected from light and moisture.
Industrial universality: Price as low as ¥1/kg (industrial grade), suitable for large-scale purchasing.
Propionyl Bromide CAS 598-22-1 Use
Purpose:
Pharmaceutical intermediates: Synthesis of antifungal drugs (such as chloropropyne iodine), amino acid derivatives.
Organic synthesis: Preparation of acyl bromide derivatives and polycarbonate monomers.
Synthesis process:
Mainstream method: Anhydrous propionic acid + bromine → red phosphorus catalysis, reaction temperature 90-100℃ → purification by vacuum distillation.
Yield: ≥73%, purity can reach 99%.
Propionyl Bromide CAS 598-22-1 safety
Hazardous characteristics:
Strong corrosiveness: Burns may occur upon contact with skin, eyes or respiratory tract (Risk Indication: R34).
Flammable and explosive: Vapor mixed with air forms an explosive mixture (flash point 52℃).
It reacts violently with water: generating hydrogen bromide and acetic acid, and releasing a pungent gas (R14).
Protective measures:
When operating, wear anti-corrosion gloves, goggles and gas masks, and carry out the operation in a fume hood.
Leakage treatment: Adsorb with sand or inert materials. Do not rinse with water.
Storage requirements:
Keep away from light, moisture and refrigeration (2-8 ℃), and keep away from oxidants, alkalis and alcohols.
