Trichloroacetic acid CAS 76-03-9
Trichloroacetic acid CAS 76-03-9Trichloroacetic acid CAS 76-03-9

Trichloroacetic acid CAS 76-03-9

Trichloroacetic acid CAS 76-03-9, Trichloroacetic, acid CAS 76-03-9

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Trichloroacetic acid CAS 76-03-9 decomposes into chloroform and carbonate when exposed to strong alkali. Toxic gases such as hydrogen chloride and carbon monoxide are released at high temperatures.

76-03-9

C2HCl3O2

163.39

200-927-2

Trichloroacetic acid CAS 76-03-9 Information

CAS 76-03-9
Molecular formula C2HCl3O2
Molecular weight 163.39
EIENCS 200-927-2
Form Solid
Melting point 54-58 °C
boling point 196 °C
Density 1.62 g/mL at 25 °C
Solubility H2O: 0.5 M at 20 °C, clear, colorless
PKA 0.7(at 25℃)
Color White
Storage temp Store at +15°C to +25°C.

Trichloroacetic acid CAS 76-03-9

What is Trichloroacetic acid CAS 76-03-9?

Molecular formula and structure

Molecular formula: C₂HCl₃O₂

Molecular weight: 163.39 g/mol

Structure: In the acetic acid molecule, the three hydrogen atoms of the methyl group are replaced by chlorine (Cl₃, CCOOH), making it a strong organic acid.

Appearance: Colorless to white crystals, hygroscopic, with a pungent odor.


It decomposes into chloroform and carbonate when exposed to strong alkali. Toxic gases such as hydrogen chloride and carbon monoxide are released at high temperatures.

Dilute solutions (<30%) are prone to decomposition and should be prepared and used immediately.


Trichloroacetic acid CAS 76-03-9 Use

1.Biochemistry and Medicine (accounting for 45%)

Protein precipitant

The precipitation of proteins through acid denaturation and exposure of hydrophobic groups is used to extract biochemical drugs such as ATP and cytochrome C.

Note: Macromolecular proteins (>100 kDa) may produce fragments due to acid hydrolysis, and the residues should be thoroughly washed off with acetone.

Pharmaceutical application

Dermatological wart remover (concentration 80-90%), astringent and hemostatic; Sodium trichloroacetate is a selective herbicide.

2. Agriculture and Industry (accounting for 35%

Pesticide intermediates: Key raw materials for the synthesis of the insecticide chlorpyrifos and the herbicide sulfoxpiazole.

Industrial Solvents and Synthesis

Introducing chlorine atoms in dye/pigment synthesis enhances stability;

Metal surface degreaser, corrosion inhibition rate >90%.

3. Analytical Chemistry (accounting for 20%

Chromatographic reagents: Separation of bile pigments, fluoride detection;

Microscopic fixative: Tissue decalcification and sample fixation.


Trichloroacetic acid CAS 76-03-9 safety

1. Health risk

  • Acute toxicity:Oral LD₅₀=3300 mg/kg in rats, intraperitoneal injection of LDL₀=500 mg/kg in mice

  • Corrosiveness:

    • Chemical burns caused by skin contact (rabbit experiment: 0.21 mg mild irritation);

    • Eye contact with 3500 μg per 5 seconds can cause blindness

  • Carcinogenicity:WHO Group 2B carcinogens (possibly carcinogenic to humans)

2. Protection and Emergency Response

Operation linkProtective requirements
Respiratory systemGas mask (concentration > Self-contained breathing apparatus is used when the concentration is 5 mg/m³.
Skin/EyeNitrile gloves + goggles + anti-corrosion work clothes
Leakage treatmentNeutralize with soda ash and then rinse with water. Incinerate the waste liquid for disposal
First aidSkin contact → Rinse with running water for 15 minutes; Eye contact → Rinse with normal saline + Seek medical attention

3. Environmental risk

  • Aquatic toxicity:Fish LC₅₀> 1000 mg/L, but prohibited discharge water bodies (the US agricultural irrigation standard is ≤0.2 mg/L)


Deshangchemical Info

  • ● Comgpany name : Shandong Deshang Chemicals Co., Ltd.
  • ● Main products : Treatments, sedimentation agents, flame retardants, catalysts, matte pigments, talcum powder, PVC additives, antifreeze agents, cellulose, cleaning agents, coconut oil, hydroxyethyl, cosmetics, matte agents, betaine, disinfectants, photosensitizers, humidifying agents, blue pigments, curing agents, potassium formate, sodium formate, cyclohexanol, preservatives, grinding aids.
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