nuciferine CAS 475-83-2, nuciferine, CAS 475-83-2
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Nuciferine CAS 475-83-2 is readily soluble in organic solvents with low polarity such as benzene, ether, chloroform, and halogenated alkanes. It also has good solubility in hydrophilic organic solvents such as acetone and ethanol, but has low solubility or is almost insoluble in water. It is in powder form and its color ranges from white to beige.
475-83-2
C19H21NO2
295.38
618-170-5
| CAS | 475-83-2 |
| Molecular formula | C19H21NO2 |
| Molecular weight | 295.38 |
| EIENCS | 618-170-5 |
| Form | powder |
| Melting point | 165.5°C |
| boling point | 437.06°C (rough estimate) |
| Density | 1.1156 (rough estimate) |
| Solubility | DMSO : 11.11 mg/mL (37.61 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble) |
| PKA | / |
| Color | / |
| Storage temp | 2-8°C |
Appearance and properties: It is readily soluble in organic solvents with low polarity such as benzene, ether, chloroform, and halogenated alkanes. It also has good solubility in hydrophilic organic solvents such as acetone and ethanol, but has low solubility or is almost insoluble in water. It is in powder form and its color ranges from white to beige.
Melting point: Different literature reports have various expressions such as 162.5-163.5℃, 165.5℃, 171.0-172.5℃, etc.
Boiling point: 430.7-437.06℃ (Different literature has different estimated values)
Density: Approximately 1.10-1.1156 (Different literatures have different estimated values)
Refractive index: 1.5000 (estimated value)
Flash point: 151.9-151.9173℃
Storage conditions: 2-8 ℃, store at low temperature and away from light
Solubility: 11.11 mg/mL in DMSO (ultrasound required); 0.1 mg/mL in water (almost insoluble)
Acidity coefficient (pKa) : 7.87±0.20 (predicted value)
Form: Powder
Optical activity: [α]/D - 145 to 165, c = 0.5 in ethanol
According to traditional Chinese medicine, lotus leaves are bitter and astringent in nature, neutral in nature, and belong to the liver, spleen, stomach and heart meridians. They have the effects of clearing summer heat and promoting diuresis, ascending clear Yang, cooling blood and stopping bleeding. Lotus leaf alkaloids, as one of the main components in lotus leaves, also have certain applications in traditional medicine, such as potentially helping to clear heat and relieve summer heat. However, there is currently insufficient modern medical evidence to support the specific mechanisms and effects of these functions.
Modern pharmacological research applications:
Lipid-lowering effect: Pharmacological studies have shown that lotus leaves have the effect of lowering lipids and removing oil. Lotus leaf alkaloid may be one of the important components that play a role in regulating blood lipids, but it cannot be equated alone with lotus leaf products that have the health care effect of regulating blood lipids. Regulating blood lipids is a complex process and is influenced by multiple factors.
Biological activity study: Nuciferine is an antagonist of 5-HT2A, 5-HT2C and 5-HT2B, with IC50 values of 478 nM, 131 nM and 1μM respectively; It is also a reverse agonist of 5-HT7, with an IC50 of 150 nM. It is also an agonist or antagonist of the 5-HT6 receptor (EC50 is 700 nM), the 5-HT1A receptor (EC50 is 3.2 μM), the D2 receptor (EC50 is 64 nM), the D4 receptor (EC50 is 2 μM), and the D5 receptor (EC50 is 2.6 μM). In vitro studies have shown that it is also an effective inhibitor of peristalsis in adult schistosomes, capable of effectively suppressing the basal and 5-HT-induced movements of adult schistosomes. The inhibitory concentrations of Schistosomule on schistosomes are 0.24±0.04 μM and 0.62±0.22 μM, respectively.
Hazard Sign (GHS) : The warning word is "danger"
Hazard description: H301 (indicates that swallowing can be fatal)
Precautions: P301 (If swallowed by mistake, do not induce vomiting), P330 (Rinse mouth), P331 (Do not inhale dust or smoke), P310 (Call the detoxification center/doctor immediately)
Safety Instructions: 24/25 (Avoid contact with eyes and skin)
Dangerous goods transportation number: UN 1544 PSN1 6.1 / PGIII
Customs Code: 29389090
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