sodium dichloroacetate CAS 2156-56-1, sodium dichloroacetate, CAS 2156-56-1
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Sodium dichloroacetate (with its unique CAS number 2156-56-1), as a compound with specific chemical properties, has demonstrated an extremely important role in numerous scientific research fields and practical application scenarios today.
2156-56-1
C2H3Cl2NaO2
152.93
218-461-3
| CAS | 2156-56-1 |
| Molecular formula | C2H3Cl2NaO2 |
| Molecular weight | 152.93 |
| EIENCS | 218-461-3 |
| Form | Powder |
| Melting point | 189-199℃ (slightly varying among different literatures) |
| boling point | 194℃（at 760 mmHg） |
| Density | The relative density (water = 1) is approximately 1.56 |
| Solubility | Methanol (Slightly), Water (Slightly) |
| PKA | / |
| Color | White |
| Storage temp | Inert atmosphere,2-8°C |
Sodium dichloroacetate (with its unique CAS number 2156-56-1), as a compound with specific chemical properties, has demonstrated an extremely important role in numerous scientific research fields and practical application scenarios today. With the characteristics bestowed by its unique chemical structure, it plays an indispensable role in multiple different professional fields and has become a key component in numerous related studies and practical applications.
Medical field
It is a medicinal component with strong anti-leukemia activity. Clinically, it is often used to treat diseases such as lactic acidosis (LA), and can be administered intravenously or orally.
It is a metabolic regulator in the mitochondria of cancer cells. As a specific inhibitor of mitochondrial pyruvate dehydrogenase kinase (PDK), the IC50 values for PDK2 and PDK4 are 183 and 80 μM respectively, and it can inhibit Na-K-2Cl-cotransporter and the mitochondrial potassium ion channel axis. Increase the generation of reactive oxygen species, cause apoptosis of cancer cells, and inhibit tumor growth. It has anti-cancer activity in various types of cancer, including colon cancer, prostate cancer, ovarian cancer, neuroblastoma, lung cancer, cervical cancer, endometrial cancer, cholangiocarcinoma, sarcoma and T-cell lymphoma.
It can also be used to treat certain metabolic diseases, such as mitochondrial diseases.
Industrial field:
It can be used as a catalyst, preservative and disinfectant.
It is used as an intermediate for the synthesis of other organic compounds, such as pesticides and dyes.
It is used as a flame retardant in industries such as plastics, rubber, textiles, fibers and papermaking. For instance, it is applied in resins like epoxy, polycarbonate, polyester, phenolic and ABS to endow the products with excellent flame retardancy and self-extinguishing properties. Currently, it is officially used in the injection of epoxy resin for high-voltage packages of televisions.
Laboratory field: As a tool compound for regulating cell metabolism research.
Hazardous materials marking: Xi (Irritating), Xn (Harmful).
Hazard Category code: 36/37/38 (Irritating to eyes, respiratory tract and skin), 40 (may have irreversible effects).
Safety Instructions: 26 (In case of contact with eyes, rinse immediately with plenty of water and seek medical attention), 37/39 (Use appropriate protective gloves and goggles), 36 (Avoid contact with eyes), 36/37 (Avoid contact with skin and eyes).
Dangerous goods transportation number: 2811.
WGK Germany: 2
RTECS number: AG9275000.
Customs Code: 29154000.
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