"Discover the versatile functions of 2-Hydroxypropyl-Beta-Cyclodextrin (CAS 128446-35-5 HPCD), a high-performance cyclodextrin derivative widely used in pharmaceuticals, food supplements, cosmetics, and biotech for solubility enhancement, active stabilization, and formulation safety."
-Deshangchemical
In today's era of rapid technological development and continuous upgrading of industrial formulas, modern pharmaceutical, food, cosmetics and biotechnology fields are facing higher challenges in formula functionalization, safety and dissolution efficiency. Consumers' attention to product quality, ingredient transparency and environmental protection continues to rise, which prompts researchers to continue to look for more ideal functional carriers. 2-hydroxypropyl-beta-cyclodextrin CAS 128446-35-5 HPCD, as a structurally modified cyclodextrin derivative, is becoming an indispensable core raw material in the formulation of high-end products in many industries with its excellent inclusion capacity, excellent water solubility and high biocompatibility.
What is 2-Hydroxypropyl-Beta-Cyclodextrin (HPCD)?
2-Hydroxypropyl-Beta-Cyclodextrin (abbreviated as HPCD) is a non-ionic, highly water-soluble cyclodextrin derivative obtained by hydroxypropylation of natural β-cyclodextrin. Its molecular structure has a hydrophobic inner cavity and a hydrophilic outer surface, which can efficiently embed hydrophobic active molecules, thereby improving their water solubility, stability and bioavailability. Due to its high safety and excellent solubility, 2-hydroxypropyl-beta-cyclodextrin has been widely used in pharmaceutical preparations, functional foods, skin care product formulations, and biological research.
Basic product information:
English name: 2-Hydroxypropyl-Beta-Cyclodextrin
CAS number: 128446-35-5
Molecular formula: C₆₃H₁₁₂O₄₉ (depending on the degree of substitution, the specific formula may vary slightly)
Appearance: white or light yellow powder
Solubility: very soluble in water, the solution is transparent and stable
Features: non-toxic, hypoallergenic, biodegradable
CAS 128446-35-5 Core advantages of HPCD
Improving the solubility of hydrophobic active ingredients
HPCD can significantly enhance the solubility of fat-soluble ingredients such as drugs, vitamins, and spices in water, solving the problem of aqueous phase formulation.
Enhanced stability and antioxidant capacity
The embedded molecules can effectively isolate the degradation reactions caused by oxygen, ultraviolet rays, and metal ions, extending the shelf life.
Masking odor and bitterness
In medicines and functional foods, 2-hydroxypropyl-beta-cyclodextrin can mask the bad smell and taste of active ingredients and improve product palatability.
High safety and international regulatory approval
HPCD has been approved by FDA, EMA, GB and other official agencies for use in food, medicine and daily chemicals, and is a highly reliable green formula raw material.
Application field analysis
1. Pharmaceutical field: ideal dissolution and delivery system for poorly soluble drugs
In drug formulations, CAS 128446-35-5 HPCD can improve the dissolution efficiency of hydrophobic drugs such as hormones, nonsteroidal anti-inflammatory drugs, and anticancer drugs, enhance drug efficacy and prolong release time. Its good inclusion ability can also be used for controlled release and targeted delivery, and it is the core carrier in preparations such as injections, eye drops, and sustained-release capsules.
2. Food and nutritional supplements: protect nutrients and stabilize flavor
In nutritional foods and plant-extracted beverages, 2-hydroxypropyl-beta-cyclodextrin CAS 128446-35-5 HPCD can be used to include unstable ingredients such as vitamin E, curcumin, tea polyphenols, and natural flavors to prevent their oxidative inactivation, improve solubility and absorption rate, and meet the requirements of clean label formulations.
3. Cosmetics and personal care products: an ideal combination of stability and mildness
HPCD is widely used in daily chemical formulas such as skin creams, essences, sunscreens, etc. to protect easily degradable ingredients such as VC, retinol, coenzyme Q10, etc., reduce skin irritation, and improve skin feel and product stability.
4. Biological science and transport research: laboratory-level scientific research aids
In cell experiments and membrane research, 2-hydroxypropyl-beta-cyclodextrin can be used as a cholesterol remover or liposome carrier. It is a key excipient in membrane protein extraction, lipid raft research and drug delivery system research.
Safety and regulatory support
GRAS certification: listed in the GRAS (Generally Recognized As Safe) list by the US FDA
EU EMA approval: used in pharmaceutical dosage forms such as injections and eye drops
Chinese Pharmacopoeia included: meets the standards for food additives and pharmaceutical excipients
Eco-friendly: naturally degradable, no pollution risk to the aquatic environment
Although the safety of 2-hydroxypropyl-beta-cyclodextrin CAS 128446-35-5 has been widely recognized, the dosage still needs to be controlled according to industry standards. For example, in injectable drugs, the daily dosage for adults is recommended not to exceed 8 grams.
Market Trends and Prospects
With the increasing popularity of green technology, clean labels and smart formula design, 2-hydroxypropyl-beta-cyclodextrin CAS 128446-35-5 HPCD is accelerating to become a strategic raw material in the fields of food, medicine and cosmetics. According to statistics, its global market is expected to grow at an average annual rate of 6.5%–8%.
In the future, HPCD will also be combined with microencapsulation technology, nano-delivery platforms, and intelligent controlled release systems to form more advanced composite materials, providing higher technical support for the development of precise formulas.
Conclusion
2-Hydroxypropyl-Beta-Cyclodextrin (CAS 128446-35-5 HPCD) is not only an efficient inclusion agent, but also a multifunctional, environmentally friendly and safe modern formula solution. It is promoting innovation and sustainable development in the pharmaceutical, food, cosmetics and biological research industries with its outstanding performance. As a representative of green functional materials, HPCD will undoubtedly play a greater role in the future intelligent, efficient and environmentally friendly product system.
