![Preparation of 4-amino-7-iodopyrrolo [2,1-f ] [1,2,4] triazine](/static/upload/image/20260812/1786524811430773.webp)
Preparation of 4-amino-7-iodopyrrolo [2,1-f ] [1,2,4] triazine
In a 2L three-necked flask, tert-butyl 1H-pyrrolo [2,1-f ] [1,2,4] triazine-1-carboxylate was added, followed by tert-butoxycarbonylhydrazine carboxylate (100g, 0.76mol), 2,5-dimethoxytetrahydrofuran (108g, 0.83mol), and dioxane (700mL). The mixture was stirred, and then slowly added dropwise with dilute hydrochloric acid (2M, 10mL) to the solution.
