"A practical supplier guide to Alpha-GPC (choline glycerophosphate, CAS 28319-77-9): what it is, its chemistry and solubility, cognitive and sports-nutrition uses, formulation and handling notes, and how it pairs with related ingredients such as choline hydroxide, L-arginine, creatine, and ginkgo."
-Deshangchemical-chemechemi
Alpha-GPC, short for L-α-glycerophosphorylcholine, is a naturally occurring phospholipid derivative that has become a standard choline raw material in cognitive-health supplements and sports-nutrition formulas. With the chemical name choline glycerophosphate and CAS number 28319-77-9, it delivers choline efficiently to the brain, where the body uses it to synthesize acetylcholine — a neurotransmitter tied to memory, focus, and muscle activation.
For formulators and procurement teams, the appeal is practical: high water solubility, a stable white powder form, and a long track record in finished products sold across Europe, North America, and Asia. This article covers the material's profile, why brands use it, and how it fits alongside related ingredients we supply.
What Alpha-GPC actually is
Chemically, Alpha-GPC is C8H20NO6P, with a molecular weight of 257.22 and EINECS reference 248-962-2. It appears as a white to off-white solid, melts around 142.5–143°C, and is extremely hygroscopic. Its water solubility is roughly 1000 g/L at 25°C, which makes it easy to work into both powder blends and liquid concentrates.
That hydrophilicity is a double-edged sword. On the one hand, it dissolves cleanly and mixes well with common excipients. On the other, it pulls moisture from the air, so storage and handling need attention. We recommend sealed, low-humidity packaging and a -20°C storage temperature to preserve flowability and prevent clumping during downstream processing. Every batch is tested before shipment, and COA, specification sheets, and supporting documents are available on request.
Why manufacturers choose it
The core function is choline delivery. Once ingested, Alpha-GPC crosses into the brain and raises available choline, supporting acetylcholine production. That single mechanism explains why it appears in two very different product categories.
In cognitive and healthy-aging supplements, Alpha-GPC is used to support memory and mental clarity, particularly in formulas aimed at older adults. It has been studied in contexts such as age-related cognitive decline and recovery support, and is sold as an OTC product in most markets. In the United States, the FDA has granted GRAS status with a recognized daily intake ceiling of about 196.2 mg, which gives formulators a concrete dosing reference.
In sports nutrition, Alpha-GPC is valued for a separate reason: studies suggest it can support natural growth-hormone release and power output during resistance and explosive-movement training. That has made it a common ingredient in pre-workout blends and strength-focused stacks, often dosed in the 300–600 mg range per serving depending on the product format.
Formulating with related ingredients
Alpha-GPC rarely works alone. Buyers often pair it with complementary actives, and we stock several that fit naturally into the same product line.
For choline-focused formulas, choline hydroxide (CAS 123-41-1) is a useful reference compound in the same chemistry family. When the goal is cognitive and circulation support, L-Arginine (CAS 74-79-3) is frequently combined with choline sources to support healthy blood flow. For sports and recovery stacks, creatine monohydrate (CAS 6020-87-7) pairs well, since both ingredients target power and training output through different pathways. And for botanical cognitive support, ginkgo biloba extract (CAS 90045-36-6) remains one of the most recognized herbal ingredients in the brain-health category.
Handling and formulation notes
Because Alpha-GPC is hygroscopic, we suggest conditioning the production room to controlled humidity and using low-shear blending to avoid generating heat that accelerates caking. In tablet formats, a modest amount of a flow agent such as silica helps; in stick packs and capsules, the powder's fine particle size generally fills cleanly. For beverage applications, its high solubility means it dissolves without turbidity at typical use levels.
Typical specifications buyers request
Most procurement teams ask for assay (commonly ≥99% for the powder, or a defined 50%/85% grade depending on the salt form), loss on drying, heavy metals, and microbial limits. Alpha-GPC is also supplied as a concentrated solution or hydrated form, not only as powder, so it is worth confirming the exact grade and moisture content with your supplier before locking a formula — the active choline content differs between grades, and that directly affects per-serving dosing. Requesting a current COA and a small sample for in-house verification keeps the scale-up process straightforward.
Quality, documentation, and supply
As a direct supplier, we focus on consistency rather than promises. Our Alpha-GPC is produced to a defined specification, sampled and tested per batch, and shipped with commercial invoice, packing list, bill of lading, COA, health certificate, and certificate of origin. Samples are available for lab verification before any volume commitment, and our team replies to inquiries within 24 hours.
One practical note for product teams: because choline can be metabolized to TMAO, some published cohort data has pointed to cardiovascular considerations at higher intakes. We always recommend that brand owners follow established GRAS dosing and local regulatory limits, and confirm claims with qualified regulatory counsel.
Ordering and support
Whether you are building a nootropic capsule, a pre-workout powder, or a healthy-aging tablet, Alpha-GPC is a proven, well-understood choline donor that fits a wide range of delivery formats. If you need pricing, lead time, or a sample of Alpha-GPC (CAS 28319-77-9), reach out to our sales team — we can usually quote the same business day and arrange testing support for your formulation work.
